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Dr Karen Hapgood

Dr Karen Hapgood

B.E. (Chemical Engineering, Hons I), University of Queensland, 1993.
Ph.D. Department of Chemical Engineering, University of Queensland, 2000

Senior Lecturer

Email: Karen.Hapgood@eng.monash.edu.au
Tel: +61 3 9905 3428
Fax: +61 3 9905 5686
Room 207, Building 69 Engineering

Research Information Page

Monash Advanced Particle Engineering Laboratory (MAPEL)

Professional Appointments

  • 2006-Present: Senior Lecturer, Department of Chemical Engineering, Monash University.
  • 2005-2006: Process Engineer, Technical Operations, Merck Sharp and Dohme Australia.
  • 2003-2005: Project Scientist, Pharmaceutical Materials Laboratory, Merck & Co., USA
  • 2001-2003: Senior Research Chemical Engineer, Pharmaceutical R&D, Merck & Co., USA
  • 1993-1996: Project Engineer, Industrial Automation & Controls, Honeywell.

Professional Affiliations

  • IChemE (Member)
  • Australasian Particle Technology Society (secretary)
  • American Association of Pharmaceutical Scientists
  • Australian Association of Engineering Education

Current Research and Professional Interests 

  • Understanding granulation processes
  • Liquid-particle interactions in processing equipment
  • Pharamceutical manufacturing processes for solid dosage forms
  • Applied powder technology
  • Pharmaceutical formulation
  • Design of particles to provide desired properties

Awards and Honours

  • 2008 Dean’s Award for Teaching Excellence
  • 2006 American Association of Pharmaceutical Scientists New Investigator award in Pharmaceutical Technology
  • 2004 Merck Pharmaceutical Technology and Engineering award for Excellence in Technology Transfer

Major Research Grants

  • 2006 American Association of Pharmaceutical Scientists, New Investigator in Pharmaceutics and Pharmaceutical Technology Award, US$25000 plus US$1500 travel subsidy.
  • 2007 Australian Research Council Discovery Project DP0770462: “Granulation of Hydrophobic Powders: design and control of granule size and structure”, $140,000 over 3 years
  • 2007 DOW Chemical Company, “Foam Granulation”, US$60,000 over 3 years.
  • 2008 Australian Research Council Discovery Project DP08: “Design of Granule Microstructure in Fluidised Bed Granulation: Modelling and Experimental Realisation”, $390,000 over three years.
  • 2008 Monash International Strategic Initiatives fund – PEERCI Pharmaceutical Engineering

Selected Publications and Presentations

Book Chapters:

  • 2008 Hapgood, K.P. and Rhodes M., “Size Enlargement”, in “Introduction to Particle Technology”, 2nd edition, M. Rhodes (ed.), John Wiley & Sons, 2008.
  • 2008 Hapgood, K.P., S.M. Iveson, L. Liu & J.D. Litster, “Granule Rate Processes”, in “Handbook of Granulation”, A. Salman, M. Hounslow and J.P.K. Seville (eds.), Elsevier Science, 2008.
     

Journal Articles:

  •  2009 Kale, K, KP Hapgood and P Stewart (2009). "Drug agglomeration and dissolution - what is the role of mixing?" European Journal of Pharmaceutical Sciences. In press, Accepted Manuscript.
  • 2009 Hapgood, KP, MXLTan and DWY Chow (2009). "Predicting nuclei size distributions in wet granulation using dimensionless spray flux." Advanced Powder Technology In Press, Accepted Manuscript.
  • 2009 Tan, M.X.L., L.S. Wong, K.H. Lum, and K.P. Hapgood, “Foam and drop penetration kinetics into loosely packed powder beds”. Chemical Engineering Science, 2009. 64(12): p. 2826-2836.
  • 2009 Hapgood, K.P., T.H. Nguyen, S. Hauw, S.M. Iveson, and W. Shen, “Rewetting effects and droplet motion on partially wetted powder surfaces”. AIChE Journal, 2009. 55(6): p. 1402-1415.
  • 2009 Hapgood KP and Khanmohammadi B, “Granulation of hydrophobic powders”, Powder Technology, 189(2): p. 253-262.
  • 2009 Michaels, JN, Farber L, Wong GS, Hapgood K, Heidel SJ Farabaugh J, Chou J-H. and Tardos GI. "Steady states in granulation of pharmaceutical powders with application to scale-up." Powder Technology, 188(3): p. 248-254.
  • 2009 Hapgood KP, Farber L and Michaels JN (2009). "Agglomeration of hydrophobic powders via solid spreading nucleation." Powder Technology 188(3): 248-254.
  • 2008 Hapgood K. and Hardin M(2008). "Tomorrow's professor." TCE 808: 54-56.
  • 2008 Farber L, Hapgood K, Michaels M, Fu X, Meter R, Johnson M, Li F, "Unified theory for tensile strength of lactose-avicel compacts made by direct compression and compression of roller compacted granules", International Journal of Pharmaceutics, 346(1-2), 17-24.
  • 2004 Hapgood KP., Litster JD., White ET, Mort PR, and Jones DG, “Dimensionless spray flux in wet granulation: Monte-Carlo simulations and experimental validation”, Powder Technology, 141: 20-30.
  • 2004 Tardos GI, Hapgood KP, Ipadeola O, and Michaels JN., “Stress measurements in High Shear Granulators using Calibrated “test” Particles: Implications for Scale-up”, Powder Technology, 140: 217-227
  • 2003 Hapgood KP, Litster JD, Smith R, “Nucleation Regime Map for Liquid Bound Granules.” AIChE Journal, 49: 350-360.
  • 2002 Hapgood K, Litster J, Biggs S., Howes T, “Drop Penetration into porous powder beds.” Journal of Colloid and Interface Science, 253: 353-366
  • 2002 Litster JD, Hapgood KP, Michaels JN, et al., “Scale-up of mixer granulators for effective liquid distribution.” Powder Technology, 124: 272-280.
  • 2001 Iveson SM, Litster JD, Hapgood KP, “Nucleation, growth and breakage phenomena in agitated wet granulation processes: a review.” Powder Technology, 117: 3-39.
  • 2001 Litster JD, Hapgood KP, Michaels JN, et al., “Liquid Distribution in Wet Granulation. Dimensionless Spray Flux.” Powder Technology, 114: 32-39.
     

Conference Proceedings:

  • 2008 Tan, MXL, and K.P. Hapgood “Foam granulation: Comparison of nucleation via drops and foams”. AIChE Annual Meeting, 16-20 Nov 2008, Philadelphia USA, AIChE.
  • 2008 Hapgood, K. “Scale-up of wet granulation processes”, 1st Asian Arden House Conference, 30 Oct -3 Nov 2008, Beijing, China, AAPS.
  • 2008 Eshtiaghi, N., J. S. Liu and K. Hapgood (2008). “Key Factors in stable Formation of Liquid marble and Hollow Granules” CHEMECA 2008, 28 Sep.-1 Oct., 2008, Newcastle, Australia, IEAust.
  • 2008 Tan, MXL, L.S. Wong, K.H. Lum and K.P. Hapgood “Foam granulation: Comparison of nucleation via drops and foams”. CHEMECA 2008, 28 Sept-1 Oct 2008, Newcastle Australia, IEAust.
  • 2007 Hapgood, K.P, S. M. Iveson, T. H. Nguyen, Sunarko and W. Shen, “Drop Motion on Partially Wetted Powder Surfaces”, CHEMECA 2007, 20-23 September 2007, Melbourne, Australia, IChemE/IEAust.
  • 2007 Hapgood, K.P, M.X.L.Tan and D. W. Y. Chow, “Predicting nuclei size distributions in wet granulation using dimensionless spray flux”, CHEMECA 2007, 20-23 September, Melbourne, Australia, IChemE/IEAust.
  • 2007 Hapgood K.P. (invited speaker)., “Granulation mechanisms”. Granulation training course, 26-27 June, Sheffield, UK, Sheffield University.
  • 2007 Hapgood K.P. (invited speaker) and Khanmohammadi B., “Granulation of hydrophobic powders”. 3rd International Workshop on Granulation, 28-29 June, Sheffield, UK, Sheffield University.